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Updated: Jul 14, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

Rifampicin induced thrombocytopenia.

Rajiv Garg¹, V Gupta, S Mehra

¹Department of Pulmonary Medicine, King George's Medical University, Lucknow. rgarg70@rediffmail.com

The Indian Journal of Tuberculosis

|June 20, 2007

Summary

Rifampicin, an anti-tubercular drug, can rarely cause life-threatening thrombocytopenia (low platelet count) due to rapid platelet destruction. This case report documents this rare adverse drug reaction.

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Last Updated: Jul 14, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

Area of Science:

Pharmacology
Hematology
Internal Medicine

Background:

Thrombocytopenia is a rare but serious complication associated with certain anti-tubercular medications.
The condition involves the rapid destruction of platelets in susceptible individuals upon exposure to specific drugs.

Observation:

This report details a specific case of thrombocytopenia.
The thrombocytopenia observed was directly induced by the anti-tubercular drug Rifampicin.

Findings:

The case highlights Rifampicin as a potential causative agent for severe thrombocytopenia.
The mechanism involves drug-induced immune-mediated destruction of platelets.

Implications:

This documentation is crucial for recognizing and managing Rifampicin-induced thrombocytopenia.
Increased awareness can aid clinicians in identifying this rare adverse drug event and preventing potentially fatal outcomes.