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Related Experiment Videos

Differentiating spitzoid melanomas from Spitz nevi through CD99 expression.

Mark S King1, Sylvia J Porchia, Kim M Hiatt

  • 1Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Journal of Cutaneous Pathology
|June 20, 2007
PubMed
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CD99 expression can help differentiate Spitz nevi (SN) from spitzoid melanoma (sMM). Most sMM cases showed CD99, while only a few SN cases did, suggesting CD99 is a useful diagnostic marker.

Area of Science:

  • Dermatopathology
  • Oncology
  • Immunohistochemistry

Background:

  • Distinguishing Spitz nevi (SN) from spitzoid melanoma (sMM) is challenging due to overlapping histological features.
  • A reliable diagnostic marker for this differentiation is currently lacking.
  • CD99, a transmembrane glycoprotein implicated in neoplastic processes, has not been previously evaluated in this context.

Purpose of the Study:

  • To investigate the expression of CD99 in Spitz nevi (SN) and spitzoid melanoma (sMM).
  • To determine if CD99 can serve as a diagnostic marker to differentiate between SN and sMM.

Main Methods:

  • Retrospective analysis of 58 Spitz nevi (SN) and 27 spitzoid melanoma (sMM) cases.
  • Immunohistochemical staining using anti-human CD99 antibody was performed on all cases.

Related Experiment Videos

  • Analysis of CD99 staining presence and pattern in both lesion types.

    • Main Results:

    • CD99 expression was detected in 15 out of 27 (56%) spitzoid melanoma (sMM) cases.
    • CD99 expression was observed in only 3 out of 58 (5%) Spitz nevi (SN) cases.
    • Strong, diffuse CD99 staining was noted in 8 sMM cases, a pattern absent in SN.

    Conclusions:

    • CD99 is expressed in a significant proportion of spitzoid melanoma (sMM) but rarely in Spitz nevi (SN).
    • The distinct expression patterns suggest CD99 is a valuable tool for differentiating sMM from SN.
    • Further research is needed to elucidate the specific role of CD99 in these melanocytic lesions.