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Updated: Jul 14, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Regioselective (site-selective) functionalization of unsaturated halogenated nitrogen, oxygen and sulfur heterocycles
1Department of Chemistry, University of York, Heslington, York, UK. ijsf1@york.ac.uk
Abstract:
This tutorial review focuses on several practical synthetic transformations utilising palladium catalysis that facilitate the synthesis of functionalized unsaturated heterocycles in a regioselective (site-selective) manner. Cross-couplings of electron-deficient, electron-neutral and electron-rich unsaturated halogenated heterocycles with various organometallic reagents, and other types of nucleophiles, are detailed. Direct arylation of electron-rich unsaturated heterocyclic compounds by C-H functionalization is also presented.
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