Related Experiment Video

Updated: Jul 14, 2026

Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
10:23

Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans

Published on: September 8, 2023

A case of Budd-Chiari syndrome with Behcet's disease and oral contraceptive usage

Türkay Akbaş1, Neşe Imeryüz, Fatih Bayalan

  • 1Department of Internal Medicine and Critical Care Unit, Marmara University School of Medicine, Istanbul, Turkey.

Rheumatology International
|June 20, 2007
PubMed

Insights

Budd-Chiari syndrome (BCS) in a Behcet's disease (BD) patient was linked to unprescribed oral contraceptive (OC) use, leading to shock and death. This highlights the critical need to investigate multiple risk factors in BCS.

Area of Science:

  • Hepatology
  • Vascular Medicine
  • Rheumatology

Background:

  • Budd-Chiari syndrome (BCS) is a rare condition characterized by hepatic venous outflow obstruction.
  • Behcet's disease (BD) is a multisystemic inflammatory disorder associated with a hypercoagulable state.
  • Oral contraceptives (OCs) are known risk factors for venous thromboembolism.

Observation:

  • A 33-year-old female with known BD presented with shock, abdominal pain, distention, nausea, vomiting, and confusion.
  • Imaging revealed inferior vena cava (IVC) obstruction and extensive hepatic vein thrombosis, consistent with BCS.
  • The patient had been using OCs for one year without her physician's knowledge.

Findings:

  • The patient was diagnosed with BCS precipitated by a combination of BD and undisclosed OC use.
  • Initial treatment included pulse methylprednisolone for BD vasculitis and attempted thrombolytic therapy.
  • Despite interventions, the patient's condition deteriorated, leading to hepatic failure and death while awaiting liver transplantation.

Implications:

  • This case underscores the multifactorial nature of BCS and the importance of identifying all potential thrombotic risk factors.
  • Clinicians should thoroughly question patients with thrombotic conditions like BD about concurrent OC use.
  • Early recognition and management of combined risk factors may improve outcomes in BCS patients.

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...