Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pneumothorax-II01:27

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
Pneumothorax II: Pathophysiology01:08

Pneumothorax II: Pathophysiology

Pneumothorax means the presence of air in the pleural space — the thin potential gap between the visceral and parietal pleura. This condition disrupts the normal pressure balance that keeps the lungs inflated, leading to partial or complete collapse of the affected lung.Normal physiologyUnder normal conditions, the pleural space maintains a slightly negative intrapleural pressure, which keeps the lungs expanded against the chest wall. This negative pressure creates a delicate balance between...
Atelectasis II: Pathophysiology01:10

Atelectasis II: Pathophysiology

Atelectasis develops when alveoli lose their air and collapse inward. Because lung tissue is naturally elastic, these air sacs shrink rather than remaining open. Collapsed alveoli are no longer ventilated, reducing their role in gas exchange. Blood flow may continue in these regions, creating a ventilation–perfusion mismatch. Clinical findings include decreased breath sounds, dullness to percussion, reduced chest expansion, and decreased tactile fremitus as sound transmission through collapsed...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytochrome b<sub>5</sub> reductase 3 overexpression and dietary nicotinamide riboside supplementation promote distinctive mitochondrial alterations in distal convoluted tubules of mouse kidneys during aging.

Aging cell·2024
Same author

Hepatocyte growth factor gene therapy enhances infiltration of macrophages and may induce kidney repair in db/db mice as a model of diabetes.

Diabetologia·2012
Same author

Quality of life and pre-operative anxiety level in patients scheduled to undergo thoracic surgery.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2011
Same author

Recurrent chylothorax in a patient with mediastinal and abdominal paragangliomas.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2010
Same author

Frequency of specific CD8+ T cells for a promiscuous epitope derived from Trypanosoma cruzi KMP-11 protein in chagasic patients.

Parasite immunology·2010
Same author

Suppressors of cytokine signaling as tumor repressors. Silencing of SOCS3 facilitates tumor formation and growth in lung and liver.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2008

Related Experiment Video

Updated: Jul 14, 2026

Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome
07:27

Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome

Published on: January 23, 2026

Syndrome after pneumonectomy.

N Baltayiannis1, N Bolanos

  • 1Department of Thoracic Surgery, Metaxa Cancer Hospital, Piraeus, Greece.

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
|June 20, 2007
PubMed
Summary

Pneumonectomy can lead to mediastinal shift syndrome, causing breathing problems due to bronchial compression. Tissue expanders and endoluminal stenting can effectively treat this rare complication.

Area of Science:

  • Thoracic Surgery
  • Pediatric Surgery
  • Pulmonology

Background:

  • Pneumonectomy, the surgical removal of a lung, can lead to a rare complication known as mediastinal shift syndrome.
  • This syndrome involves excessive displacement of mediastinal structures into the empty pleural space, particularly in pediatric patients.
  • It can result in severe respiratory compromise due to contralateral bronchial compression.

Purpose of the Study:

  • To describe the pathophysiology, clinical presentation, and diagnostic methods for mediastinal shift syndrome post-pneumonectomy.
  • To outline effective treatment strategies for this unusual complication.

Main Methods:

  • Review of clinical presentations and diagnostic findings in patients with mediastinal shift syndrome.
  • Analysis of treatment outcomes using tissue expanders and endoluminal stenting.

More Related Videos

Mouse Pneumonectomy Model of Compensatory Lung Growth
09:22

Mouse Pneumonectomy Model of Compensatory Lung Growth

Published on: December 17, 2014

Related Experiment Videos

Last Updated: Jul 14, 2026

Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome
07:27

Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome

Published on: January 23, 2026

Mouse Pneumonectomy Model of Compensatory Lung Growth
09:22

Mouse Pneumonectomy Model of Compensatory Lung Growth

Published on: December 17, 2014

Main Results:

  • Mediastinal shift syndrome typically presents with dyspnea months to years after pneumonectomy.
  • Diagnosis is confirmed via computed tomographic scan or bronchoscopy, revealing significant tracheobronchial obstruction.
  • Right pneumonectomy carries a higher risk compared to left pneumonectomy.

Conclusions:

  • Mediastinal shift syndrome is a serious, albeit uncommon, complication of pneumonectomy requiring prompt diagnosis and intervention.
  • Restoration of mediastinal structure alignment with tissue expanders is the primary treatment.
  • Endoluminal stenting offers an efficient solution for associated tracheomalacia.