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Related Experiment Video

Updated: Jul 14, 2026

Subretinal Implantation of RPE on a Carrier in Minipigs: Guidelines for Preoperative Preparations, Surgical Techniques, and Postoperative Care

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Tixocortol pivalate: what is the right concentration?

Manjunatha Kalavala¹, Barry N Statham, Cathy M Green

¹Department of Dermatology, Singleton Hospital, Swansea SA2 8QA, UK. manjuk04@yahoo.com

Contact Dermatitis

|June 20, 2007

Summary

Tixocortol pivalate (TP) at 1% and 0.1% concentrations showed no significant difference in patch testing for hydrocortisone allergy. For screening purposes, the 1% concentration of TP is recommended for standard patch testing series.

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Area of Science:

Dermatology
Allergology
Contact Dermatitis

Background:

Tixocortol pivalate (TP) is a key marker for identifying hydrocortisone allergy.
Optimal concentration of TP for standard patch testing remains debated.

Purpose of the Study:

To determine the appropriate concentration of Tixocortol pivalate (TP) for inclusion in standard patch testing series.
To compare the efficacy of 1% TP versus 0.1% TP in patch testing.

Main Methods:

A multicenter study involving 3747 dermatitis patients patch tested with TP 1% and 0.1% in petrolatum.
Data collected from August 2004 to December 2005 across 9 UK centers.
Statistical analysis using STATISTICA version 6, including a two-tailed difference in proportions test.

Main Results:

41 patients exhibited positive reactions of clinical relevance.
20 patients were positive for both 1% and 0.1% TP concentrations.
13 patients reacted only to 1% TP, while 8 reacted only to 0.1% TP. No statistically significant difference was found between the two concentrations (P=0.21).

Conclusions:

There is no statistically significant difference in reactivity between 1% and 0.1% Tixocortol pivalate concentrations in patch testing.
Given practical limitations on the number of allergens in standard series, 1% TP is recommended for screening purposes.