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Updated: Jul 14, 2026

Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro
Published on: June 20, 2018
Solitary congenital granular cell lesion of the tongue
Hitomi Senoo1, Seiji Iida, Mitsunobu Kishino
1First Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan.
Abstract:
Congenital granular cell lesion (CGCL) is well known to appear as the congenital epulis, predominantly on the median maxillary alveolar ridge. This lesion rarely occurs on the tongue, and only 7 cases, including 4 cases with simultaneous occurrence on the alveolar ridge, have been reported in the English literature. In this report, we report a case of congenital granular cell lesion seen on the tongue. The patient was a 7-day-old Japanese girl who presented with a polypoid mass on the anterior ventral surface near the tip of the tongue. The lesion was excised at 4 months, and its histological examination revealed large granular cells. Immunochemical staining by S-100 was negative, and it was diagnosed as congenital granular cell lesion.
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