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Updated: Jul 14, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

Aggregation drives "misfolding" in protein amyloid fiber formation

Shaohua Xu1

  • 1Biological Sciences Department, Florida Institute of Technology, Melbourne, FL 32901, USA. xshaohua@fit.edu

Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis
|June 20, 2007
PubMed
Summary

Protein aggregation into amyloid fibers may be driven by surface energy minimization, not solely by misfolding. This model suggests aggregation causes conformational changes, challenging the traditional view that misfolding initiates fiber formation.

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