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Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
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Declining mortality from smoking in the United States.

Brad Rodu1, Philip Cole

  • 1Department of Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA. brad.rodu@louisville.edu

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
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Smoking-attributable deaths in the U.S. decreased by 35% between 1987 and 2002. This significant reduction in smoking-related mortality reflects the declining prevalence of cigarette use in America.

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Area of Science:

  • Public Health
  • Epidemiology
  • Biostatistics

Background:

  • Cigarette smoking prevalence in the U.S. has decreased by 50% since 1965.
  • The impact of this reduction on mortality has been largely unexamined.

Purpose of the Study:

  • To quantify the effect of reduced smoking prevalence on mortality in the U.S. between 1987 and 2002.
  • To analyze trends in smoking-attributable deaths and mortality rates.

Main Methods:

  • Utilized U.S. national data to identify current, former, and never-smokers aged 35+ in 1987 and 2002.
  • Employed mortality rate ratios to estimate smoking-attributable deaths.
  • Calculated age-adjusted smoking-attributable mortality rates (SAMRs).

Main Results:

  • Total smoking-attributable deaths decreased from 402,000 in 1987 to 322,000 in 2002.
  • The male SAMR declined 41% (from 556 to 329 per 100,000), and the female SAMR declined 30% (from 175 to 122 per 100,000).
  • Overall U.S. mortality rate attributable to smoking decreased by approximately 35% during the study period.

Conclusions:

  • A substantial decline in smoking-attributable mortality occurred between 1987 and 2002.
  • Continued decreases in smoking prevalence are expected to further reduce the public health burden of smoking.
  • Public health interventions targeting smoking cessation remain critical.