Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-Thymocyte Globulin Treatment of Steroid-Refractory T-Cell Hepatitis in Children: A Case Series.

Gastro hep advances·2025
Same author

Neuromyelitis Optica Spectrum Disorder Manifested by Persistent Hiccups and Severe Esophagitis in an Adolescent Patient.

JPGN reports·2023
Same author

Creation of a neopylorus after pyloric exclusion using a "double-endoscope" technique.

Surgical endoscopy·2015
Same author

Eosinophilic esophagitis in patients with esophageal atresia and chronic dysphagia.

World journal of gastroenterology·2014
Same author

Functional and anatomical outcomes for intravitreal bevacizumab treatment of choroidal neovascularization in a patient with angioid streaks.

Retinal cases & brief reports·2014
Same author

Metabolic control and diabetic retinopathy.

Current diabetes reviews·2009

Related Experiment Video

Updated: Jul 14, 2026

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
14:54

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy

Published on: November 29, 2015

Ischemic optic neuropathy.

Monica Rodriguez Fontal1, John B Kerrison, Reinaldo Garcia

  • 1Retina and Neuro-Ophthalmology Division, Charleston Neuroscience Institute, Charleston, South Carolina 29414-5741, USA.

Seminars in Neurology
|June 20, 2007
PubMed
Summary

Ischemic optic neuropathies (IONs) are common acute optic nerve conditions in older adults. They are categorized by location (anterior/posterior) and cause, impacting vision suddenly.

More Related Videos

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
06:49

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)

Published on: November 20, 2016

System for Focal, Closed-System Central Nervous System Injury
04:02

System for Focal, Closed-System Central Nervous System Injury

Published on: November 29, 2024

Related Experiment Videos

Last Updated: Jul 14, 2026

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
14:54

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy

Published on: November 29, 2015

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
06:49

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)

Published on: November 20, 2016

System for Focal, Closed-System Central Nervous System Injury
04:02

System for Focal, Closed-System Central Nervous System Injury

Published on: November 29, 2024

Area of Science:

  • Ophthalmology
  • Neurology

Background:

  • Ischemic optic neuropathies (IONs) are the most frequent acute optic neuropathies in individuals over 50.
  • IONs are classified by ischemic damage location (anterior vs. posterior) and etiology (e.g., temporal arteritis).

Purpose of the Study:

  • To review the classification and clinical presentation of anterior and posterior ischemic optic neuropathies.

Main Methods:

  • Literature review of ischemic optic neuropathies.
  • Analysis of classification systems based on location and etiology.
  • Summary of clinical findings for anterior and posterior ION.

Main Results:

  • Anterior ION: sudden, painless visual loss over hours to days; characterized by decreased visual acuity, visual field defects, color vision loss, relative afferent pupillary defect, and optic disc swelling.
  • Posterior ION: occurs in arteritic, nonarteritic, and surgical contexts; presents with acute vision loss, initially without disc edema, followed by optic disc atrophy.

Conclusions:

  • Understanding the distinct presentations of anterior and posterior ION is crucial for diagnosis and management.
  • IONs represent a significant cause of acute vision loss in the elderly, necessitating prompt recognition.