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Related Concept Videos

Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: Jul 14, 2026

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

Are postnatal hemangioblasts generated by dedifferentiation from committed hematopoietic stem cells?

Gregor A Prindull1, Eitan Fibach

  • 1Department of Pediatrics,University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany. gregorprindull@aol.com

Experimental Hematology
|June 20, 2007
PubMed
Summary

Cell dedifferentiation, a reversible process, is guided by epigenetic memory and chromatin changes. This review suggests dedifferentiation generates hemangioblasts from hematopoietic stem cells during development.

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Epigenetics

Background:

  • Cell dedifferentiation is observed across various cell systems.
  • It is hypothesized to exist in a reversible equilibrium with cell differentiation.
  • Intercellular signals are believed to trigger the shift towards differentiation.

Purpose of the Study:

  • To review the molecular mechanisms underlying cell dedifferentiation.
  • To propose a model for dedifferentiation in hematopoietic development.
  • To explore the role of epigenetic memory and chromatin structure.

Main Methods:

  • Literature review of molecular mechanisms of cell dedifferentiation.
  • Analysis of epigenetic regulation and chromatin dynamics.
  • Hypothesizing developmental pathways based on existing data.

Main Results:

  • Dedifferentiation appears to be regulated by structural rearrangements of nuclear chromatin.
  • Epigenetic cell memory, stored as silenced genes in heterochromatin, directs this process.
  • Gene transcription may exist in reversible, fluctuating states during cell cycles.

Conclusions:

  • Cell dedifferentiation is a dynamic process influenced by epigenetic factors and chromatin.
  • Postnatal hemangioblasts may arise from the dedifferentiation of committed hematopoietic stem cells.
  • This process offers a new perspective on hematopoietic development.