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Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
Published on: June 30, 2019
[Human and bovine tuberculosis in Latin America: from the studies about virulence to some tools for its control]
Luz Maria López Marín1, Fernando Díaz Otero, Antonio Javier Vallecillo Maza
1Instituto de Investigaciones Biomédicas, Dpto. de Inmunologia, Universidad Nacional Autónoma de Mexico, Circuito Escolar s/n, Ciudad Universitaria, 04510, Mexico, D. F. lmlm@servidor.unam.mx
Abstract:
Human and bovine tuberculosis (TB) are currently a serious health problem in Latin America. Although the causal agents were discovered more than one century ago, the control of these illnesses is still beyond our reach: human TB accounts for more than one hundred deaths each day in this region, whereas bovine TB represents a public health risk as well as a major economic problem. We herein analyze the situation of human and bovine TB in Latin America, and present studies from our laboratories on bacterial virulence factors, intrinsic resistance features in the host, and the protective response induced in cattle through vaccination or immunization. Finally, the convenience for implementing and/or revising the use of currently available tools for TB control in the region is discussed.
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