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Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Formation of Lipopolysaccharides01:19

Formation of Lipopolysaccharides

Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin, triggering...
Lipid Absorption01:24

Lipid Absorption

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What are Lipids?

Overview
What are Lipids?01:31

What are Lipids?

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Related Experiment Video

Updated: Jul 14, 2026

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

[Lipoprotein (a)].

L Zlatohlávek1, K Zídková, M Vrablík

  • 1III. interní klinika 1. lékarské fakulty UK a VFN Praha. l.zlato@tiscali.cz

Vnitrni Lekarstvi
|June 21, 2007
PubMed
Summary

Lipoprotein (a) [Lp (a)] is a plasma lipoprotein linked to atherosclerosis risk. Surprisingly, high Lp (a) levels in old age may indicate longevity due to its role in tissue repair and anti-cancer effects.

Area of Science:

  • Cardiovascular Biology
  • Human Genetics
  • Lipid Metabolism

Context:

  • Lipid transport in blood is mediated by lipoproteins.
  • Lipoprotein (a) [Lp (a)], identified in 1963, is a distinct human plasma lipoprotein.
  • Lp (a) comprises apolipoprotein (a) and low-density lipoprotein (LDL) particles (apolipoprotein B100).

Purpose:

  • To review the composition and genetic determination of Lp (a).
  • To examine the association between Lp (a) levels and atherosclerosis risk.
  • To explore the potential protective roles of Lp (a) in aging and disease.

Summary:

  • Lp (a) levels and size are highly variable and genetically determined.
  • Elevated Lp (a) concentrations (over 35 mg/dl) are linked to increased atherosclerosis risk, though findings require further validation.

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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

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Last Updated: Jul 14, 2026

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

  • Paradoxically, high Lp (a) levels in elderly individuals correlate with longevity, suggesting roles in tissue repair, wound healing, and anti-cancer activity.

    • Impact:

    • Highlights the complex, dual role of Lp (a) in cardiovascular health and aging.
    • Underscores the need for further research into Lp (a)'s physiological functions beyond atherogenesis.
    • Provides a basis for understanding genetic predispositions to cardiovascular disease and longevity.