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[Comparative study of lumbar spondylolisthesis treated by three different materials]
Rongchi Xiao1, Qiang Li, Zhihong Tang
1Department of Orthopedic Surgury, the Affiliated Hospital of Guilin Medical College, Guilin Guangxi, 541001, P. R. China. xrongchi@sina.com
Summary
Bone morphogenetic protein (BMP) with artificial bone material and cage fusion offers superior fusion rates and reduced disc height loss for lumbar spondylolisthesis compared to ilium autografts or standard cages. This method proves effective for treating this spinal condition.
Area of Science:
- Spine surgery
- Orthopedic surgery
- Biomaterials in fusion
Background:
- Lumbar spondylolisthesis is a degenerative spinal condition requiring surgical intervention.
- Interbody fusion techniques aim to stabilize the spine and promote bone healing.
- Various graft materials, including autografts, cages, and bone morphogenetic proteins (BMPs), are used in spinal fusion.
Purpose of the Study:
- To compare the clinical and radiographic outcomes of different interbody fusion materials for lumbar spondylolisthesis.
- To evaluate autografts of ilium, interbody fusion cages, and BMP/artificial bone material/cage constructs.
Main Methods:
- A prospective study of 114 patients with lumbar spondylolisthesis undergoing posterior lumbar interbody fusion and pedicle screw fixation.
- Patients were divided into three groups: ilium autograft (n=42), interbody fusion cage (n=36), and BMP/artificial bone material/cage (n=36).
- Clinical and radiographic outcomes were assessed and compared among the groups.
Main Results:
- No significant differences in surgical time, blood loss, or pre-operative disc space height were observed.
- Excellent and good clinical outcomes were achieved in over 80% of patients across all groups.
- The BMP/artificial bone material/cage group demonstrated a significantly higher fusion rate (97.0%) and lower loss of disc space height compared to the other groups.
Conclusions:
- Bone morphogenetic protein (BMP)/artificial bone material/cage is an effective method for treating lumbar spondylolisthesis.
- This approach yields superior fusion rates and better maintenance of disc space height.
- The study highlights the efficacy of BMP-based materials in spinal fusion.
