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Multi-centered clinical study on effects of nano-amomi paste in treating children's anorexia
1Department of Traditional Chinese Medicine, Affiliated Xinhua Hospital of Medical College of Shanghai Jiaotong University, Shanghai 200092. minwu@eastday.com
Insights
Nano-Amoni Paste (nmAP) effectively treats children's anorexia (AR) with no adverse reactions. This study confirms nmAP as a safe and beneficial option for pediatric AR management.
Area of Science:
- Pediatric Gastroenterology
- Traditional Chinese Medicine
- Pharmacology
Background:
- Children's anorexia (AR) presents a significant clinical challenge.
- Current treatment options for pediatric AR require further investigation for efficacy and safety.
Purpose of the Study:
- To evaluate the therapeutic effect and safety of nano-Amoni Paste (nmAP) for children diagnosed with anorexia.
- To compare nmAP's efficacy against established control treatments in a pediatric population.
Main Methods:
- A randomized, double-blinded, parallel-controlled trial was conducted with 180 pediatric patients diagnosed with AR.
- Patients were divided into three groups: nmAP treatment, positive control, and negative control.
- Treatment involved topical application of nmAP or placebo paste combined with oral liquids over two 10-day courses.
Main Results:
- The nmAP group demonstrated high total effective rates (85.0%) and cardinal symptom effective rates (95.0%).
- Significant improvements were observed in food intake, appetite, complexion, and reduced restlessness across all groups (P<0.05).
- No adverse reactions were reported in any treatment group, indicating a favorable safety profile.
Conclusions:
- Nano-Amoni Paste (nmAP) is a safe and effective therapeutic agent for treating children's anorexia.
- The findings support the use of nmAP as a viable treatment option for pediatric AR.
Objective:
To assess the effect and safety of nano-Amoni Paste (nmAP) in the treatment of children's anorexia (AR).
Methods:
One hundred and eighty patients of AR were assigned according to the randomized, double-blinded, double-simulated and parallel controlled principle to three groups, the treated group (TG), the positive control group (PCG) and the negative control group (NCG), 60 in each group. The patients in TG were treated by sticking 1.5 ml of nmAP on the acupoint of Shenque (Ren 8) once a day and orally taking placebo liquid 10 ml twice a day; those in PCG and NCG treated with sticking paste of placebo on Ren 8, and oral taking of Shanmai Jianpi Oral Liquid and placebo liquid respectively, 10 ml each time twice per day. The course of treatment for all was 10 days, all patients were treated for 2 courses.
Results:
The total effective rate and the effective rate on cardinal symptom in TG was 85.0% and 95.0% respectively, that in PCG 86.2% and 96.55% and in NCG 45.5% and 65.45%, respectively, showing significant difference between groups (P<0.05). Comparison of the clinical manifestation before and after treatment showed significant improvement in volume of food intake, appetite, complexion and reduction of restlessness symptom (P<0.05) in all three groups, and there was no adverse reaction found in them.
Conclusion:
nmAP is an effective and safe remedy for treatment of Children's anorexia.
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