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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Published on: December 11, 2016

Relationship between polypharmacy and underprescribing.

Mascha A J Kuijpers1, Rob J van Marum, Antoine C G Egberts

  • 1Department of Geriatric Medicine, University Medical Centre, Utrecht, the Netherlands.

British Journal of Clinical Pharmacology
|June 21, 2007
PubMed
Summary

Polypharmacy, the use of five or more medications, is linked to underprescribing in geriatric patients. This study found a significant association, highlighting a critical issue in elderly care.

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Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Healthcare Policy

Background:

  • Underprescribing is a growing concern in patient care.
  • Identifying factors contributing to underprescribing is crucial for improving treatment outcomes.

Purpose of the Study:

  • To investigate the relationship between polypharmacy and underprescribing in geriatric patients.
  • To quantify the association between the number of medications used and the likelihood of underprescribing.

Main Methods:

  • Compared medication regimens of 150 geriatric patients against general practitioner and national guidelines.
  • Defined underprescribing as the absence of an indicated drug without a clear reason.
  • Defined polypharmacy as the concurrent use of five or more drugs.

Main Results:

  • Polypharmacy was identified in 61% of the study population.
  • Underprescription occurred in 31% of patients.
  • Patients with polypharmacy had a significantly higher rate of underprescription (42.9%) compared to those on four or fewer medications (13.5%), with an odds ratio of 4.8.

Conclusions:

  • A clear and significant relationship exists between polypharmacy and underprescribing in geriatric patients.
  • The probability of underprescription increases with the number of drugs a patient is taking.