Related Experiment Video
Updated: Jul 14, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Migraine comorbidity constellations
Gretchen E Tietjen1, Nabeel A Herial, Jacqueline Hardgrove
1Department of Neurology, The University of Toledo College of Medicine, Toledo, OH 43614, USA.
Headache
|June 21, 2007
Summary
Migraine patients exhibit distinct comorbidity patterns, including cardiovascular/metabolic issues or mental health conditions. These groups differ in demographics, headache characteristics, and psychosocial factors, impacting migraine management.
Area of Science:
- Neurology
- Psychiatry
- Epidemiology
Background:
- Migraine is a complex neurological disorder often accompanied by comorbid conditions.
- Understanding these comorbidities is crucial for effective migraine management.
Purpose of the Study:
- To identify distinct clusters of comorbid disorders in migraine patients.
- To analyze demographic, headache, and psychosocial differences among these clusters.
Main Methods:
- Retrospective electronic chart review of 223 new female migraine outpatients.
- Cluster analysis based on non-headache comorbidities.
- Data collection on demographics, headache profiles, and psychosocial factors.
Main Results:
- Three distinct comorbidity groups were identified: 1) cardiovascular/metabolic disorders, 2) mental health/fibromyalgia, and 3) no defining comorbidities.
- Group 1 was older with later headache onset; Group 2 experienced greater disability and lower quality of life.
- Group 2 reported higher rates of past abuse (sexual, physical, emotional).
Conclusions:
- Migraine comorbidity presents as heterogeneous constellations, not a monolithic entity.
- These distinct groups suggest varied underlying genetic and environmental influences.
- Identifying these patterns can inform personalized diagnosis and treatment strategies for migraine.
Related Concept Videos
01:29Increased Intracranial Pressure ll: Pathophysiology
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:14Increased Intracranial Pressure l: Introduction
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
01:13Seizures: Classification
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
01:19Seizures ll: Types
Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...