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Updated: Jul 14, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Chronic daily headache in hereditary hemochromatosis treated by venesection
Abstract:
Coincidence or causality between iron overload and headaches (e.g., daily headache, migraine, and cluster headache) is still under discussion. Herein we report a patient suffering from hereditary hemochromatosis (homozygous C282Y mutation; OMIM: 235220, Locus 6p21.3) and daily headache fulfilling the IHSD-2 criteria of chronic migraine. Three treatments by venesection improved the headache substantially in frequency, intensity, and duration of attacks. We suggest treatment by venesection for iron depletion in patients suffering from hemochromatois and headache.
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