Clinical use of the five-factor model: an introduction
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Updated: Aug 19, 2026

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
Published on: April 25, 2012
1Laboratory of Personality and Cognition, Gerontology Research Center, Baltimore, MD 21224.
Abstract:
In the past decade, clinical psychologists have developed a renewed appreciation of the value of assessment. At the same time, personality psychologists have come to agree on a fundamental taxonomy of personality traits, the five-factor model. Articles in this special series describe the model and its measurement and discuss applications in three different settings: general clinical practice, a sexual behaviors consultation unit, and a behavioral medicine clinic. This introduction raises questions about the use of personality profiles in psychodiagnosis, the range of applicability of the five-factor model, the utility of personality feedback in psychotherapy, the stability of personality scores among psychotherapy patients, and the feasibility of using personality scores to select optimal forms of treatment. This special series is intended to stimulate research on such topics.
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