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Tear function and ocular surface changes in multinodular goiter patients

Turgut Cavusoglu1, Ayse Burcu Nurozler, Cengiz Titiz

  • 1General Surgery Clinic, Ankara Training and Research Hospital, TR-06550 Oran, Ankara, Turkey. turgutcavusoglu@gmail.com

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|June 21, 2007
PubMed
Abstract

Insights

Multinodular goiter (MNG) surgery can significantly impact ocular surface health, leading to reduced tear function and goblet cell density. Postoperative monitoring for these eye changes is recommended.

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Surgical Research

Background:

  • Multinodular goiter (MNG) is a common endocrine disorder.
  • Thyroidectomy is a standard surgical treatment for MNG.
  • Ocular surface changes following thyroidectomy are not well-documented.

Purpose of the Study:

  • To assess conjunctival surface and tear function changes in MNG patients.
  • To compare pre- and postoperative ocular findings with healthy controls.

Main Methods:

  • Tear function tests (Schirmer, BUT, Rose Bengal staining) and conjunctival impression cytology were performed.
  • Twenty MNG patients undergoing near-total thyroidectomy were evaluated preoperatively and at 3 months and 1 year postoperatively.
  • Fifteen healthy volunteers served as the control group.

Main Results:

  • Postoperative tear function (Schirmer, BUT) decreased, while Rose Bengal staining increased significantly by the 1st year (p < 0.001).
  • Goblet cell density significantly decreased postoperatively (p < 0.001).
  • MNG patients showed significant differences in ocular findings compared to controls, both pre- and postoperatively.

Conclusions:

  • Thyroidectomy for MNG significantly alters ocular surface parameters.
  • Ocular surface changes in MNG patients differ from healthy individuals.
  • Regular ophthalmological follow-up is advised for MNG patients post-thyroidectomy.

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