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Updated: Jul 14, 2026

Polarization-Sensitive Two-Photon Microscopy for a Label-Free Amyloid Structural Characterization
Published on: September 8, 2023
Stokes polarimetry in multiply scattering chiral media: effects of experimental geometry
Xinxin Guo1, Michael F G Wood, I Alex Vitkin
1Division of Biophysics and Bioimaging, Ontario Cancer Institute, Toronto, Canada. xguo@uhnres.utoronto.ca
Abstract:
The spatial distribution of optical rotation alpha and surviving linear polarization fraction beta(L) of light scattered from cylindrical turbid chiral (glucose-containing) and achiral samples is studied using a linear Stokes polarimeter. alpha and beta(L) are measured in and off the incident plane as the detection angle changes from the forward to the backward direction. The experimental results exhibit a complex dependence on the detection geometry: alpha is more sensitive to glucose presence off the incident plane, whereas beta(L) exhibits larger effects in-plane, as validated by polarization sensitive Monte Carlo simulations. A rigorous methodology is presented for optimizing the experimental geometry in the polarimetric examinations of complex random systems.
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