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Alternative splicing: a bioinformatics perspective.

Elisa Napolitano Ferreira1, Pedro A F Galante, Dirce Maria Carraro

  • 1Ludwig Institute for Cancer Research, São Paulo branch, Hospital A. C. Camargo, São Paulo, Brazil. eferreira@ludwig.org.br

Molecular Biosystems
|June 21, 2007
PubMed
Summary
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Alternative splicing generates remarkable diversity at the transcriptome and proteome levels. This review focuses on bioinformatics strategies for identifying alternative splicing events.

Area of Science:

  • Molecular Biology
  • Bioinformatics

Background:

  • Alternative splicing is a key mechanism generating proteomic and transcriptomic diversity.
  • Understanding alternative splicing is crucial for comprehending gene expression regulation.

Purpose of the Study:

  • To review current challenges and advancements in alternative splicing research.
  • To highlight bioinformatics-based identification strategies for alternative splicing.

Main Methods:

  • Literature review of alternative splicing research.
  • Focus on computational and bioinformatics approaches for splice variant identification.

Main Results:

  • The astonishing diversity generated by alternative splicing is discussed.
  • Various bioinformatics tools and techniques for identifying alternative splicing are presented.

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Conclusions:

  • Alternative splicing significantly expands the coding potential of genomes.
  • Bioinformatics plays a pivotal role in deciphering alternative splicing patterns and their functional implications.