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Weighted estimating equations for longitudinal studies with death and non-monotone missing time-dependent covariates
Michelle Shardell1, Ram R Miller
1Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD 21201, U.S.A. mshardel@epi.umaryland.edu
Abstract:
We propose a marginal modeling approach to estimate the association between a time-dependent covariate and an outcome in longitudinal studies where some study participants die during follow-up and both variables have non-monotone response patterns. The proposed method is an extension of weighted estimating equations that allows the outcome and covariate to have different missing-data patterns. We present methods for both random and non-random missing-data mechanisms. A study of functional recovery in a cohort of elderly female hip-fracture patients motivates the approach.
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