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Updated: Jul 14, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Interferons: the pathways of discovery. II. Immunomodulatory, in vivo and applied aspects

Alfons Billiau1

  • 1Rega Institute, University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium. Alfons.Billiau@Rega.Kuleuven.be

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|June 21, 2007
PubMed

This article analyzes the conceptual and technological context in which, over a period of 50 years, exploration of the biological and clinical significance of type I interferon has evolved. The elaboration of techniques for production and purification of mouse and human interferons and the establishment of laboratory-size production units have been of crucial importance in this process. Animal experiments have been invaluable for elucidation of mechanisms underlying the in vivo antiviral, anti-tumour and immunomodulatory potential of interferon, but have been of limited help to define the areas of clinical applicability. Proof of principle for applications as they are established today has come from clinical trials performed quite independently of evidence from animal experiments.

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