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To bite the bullet of early graft nephrectomy: a case report

A Pradhan1, S Gadela, R S V Kumar

  • 1Command Hospital, Department of Urology, Era's Lucknow Medical College, Hardoi Road, Lucknow, Uttar Pradesh 226002, India.

Transplantation Proceedings
|June 21, 2007
PubMed

Insights

Isolated renal allograft mucormycosis is a rare fungal infection in kidney transplant patients. Early amphotericin B treatment and graft nephrectomy are crucial for patient survival in this critical condition.

Area of Science:

  • Nephrology
  • Transplant Surgery
  • Mycology

Background:

  • Isolated renal allograft mucormycosis is an extremely rare complication following kidney transplantation.
  • Only eight cases have been documented globally, with a low patient survival rate of 37.5%.

Observation:

  • A case presented with fever and graft dysfunction unresponsive to antibiotics and supportive care.
  • Diagnosis of mucormycosis was confirmed after three renal allograft biopsies.
  • The patient underwent urgent graft nephrectomy but succumbed to septicemia.

Findings:

  • Delayed diagnosis and treatment contributed to the poor outcome.
  • Mucormycosis requires prompt recognition and aggressive management.

Implications:

  • Early initiation of amphotericin B and prompt graft nephrectomy are vital for salvaging patients with renal allograft mucormycosis.
  • This case underscores the importance of considering rare fungal infections in transplant recipients with graft dysfunction.

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