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Related Experiment Video

Updated: Jul 14, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

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Reversible renal allograft dysfunction and proteinuria from nutcracker-like syndrome: a case report.

S G S Krishnan¹, J Pritsiolas, M Susin

¹Division of Kidney Diseases/Hypertension, North Shore University Hospital, 100 Community Drive, Great Neck, NY 11021, USA.

Transplantation Proceedings

|June 21, 2007

Summary

Recurrent lymphocele caused nutcracker-like syndrome, leading to kidney transplant dysfunction. Surgical drainage resolved the allograft dysfunction and proteinuria.

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A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

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Area of Science:

Nephrology
Transplant Surgery
Vascular Surgery

Background:

A 27-year-old male with hypertension and renal failure underwent a living donor kidney transplant.
He initially showed good graft function with serum creatinine at 1.7 mg/dL and a urine protein creatinine ratio of 0.1 g/g.

Observation:

The patient experienced recurrent allograft dysfunction with elevated creatinine and proteinuria.
These episodes were associated with a lymphocele causing renal vein compression, identified via Doppler studies.

Findings:

The allograft dysfunction and proteinuria were attributed to a recurrent lymphocele.
This lymphocele created a nutcracker-like syndrome, compressing the renal vein.

Implications:

Prompt diagnosis and management of lymphocele are crucial for maintaining kidney transplant function.
Surgical intervention, such as fluid aspiration and drainage, can effectively resolve lymphocele-induced allograft dysfunction.