Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Menopause

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Role of Vitamins in Maintaining Bone Health

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Camurati-Engelmann disease in a family from Croatian Island: an old bone scan confirmed pattern of inheritance.

Collegium antropologicum·2014

Same author

[Croatian Society of Endocrinology guidelines for the diagnosis and treatment of acromegaly].

Lijecnicki vjesnik·2012

Same author

Gene expression in visceral and subcutaneous adipose tissue in overweight women.

Frontiers in bioscience (Elite edition)·2012

Same author

Prevalence and five-year cumulative incidence of abdominal obesity in Croatian women of childbearing age: the CroHort study.

Collegium antropologicum·2012

Same author

Simultaneous analysis of mitotane and its main metabolites in human blood and urine samples by SPE-HPLC technique.

Biomedical chromatography : BMC·2012

Same author

[Visceral obesity].

Lijecnicki vjesnik·2011

Search research articles

Related Experiment Videos

[Pathophysiology of postmenopausal osteoporosis].

Mirko Korsić¹

¹Zavod za endokrinologiju i bolesti metabolizma, Klinika za unutarnje bolesti Klinicki bolnicki centar Zagreb, Kispatićeva 12, 10000 Zagreb.

|June 22, 2007

Summary

Osteoporosis is a major public health issue linked to fractures. Understanding its complex causes, including genetics and environment, is key for prevention and treatment.

Area of Science:

Bone biology and molecular mechanisms
Public health and epidemiology
Genetics and environmental influences on bone health

Context:

Osteoporosis poses a significant public health challenge due to its strong association with fractures.
The development of osteoporosis involves a complex interplay of genetic and environmental factors.
Peak bone mass acquisition and the rate of bone loss are influenced by these multifactorial determinants.

Purpose:

To highlight the intricate pathophysiology of osteoporosis.
To emphasize the importance of understanding molecular mechanisms in bone formation and remodeling.
To underscore the necessity of comprehending factors influencing bone quality for effective disease management.

Summary:

Osteoporosis is a complex disease influenced by genetic and environmental factors affecting bone mass and loss.

Related Experiment Videos

Recent advancements have improved our understanding of bone formation, remodeling, and quality.

Knowledge of postmenopausal osteoporosis pathophysiology is crucial for its prevention and treatment.

Impact:

Improved understanding of osteoporosis pathophysiology can lead to more effective prevention strategies.
Enhanced knowledge of molecular mechanisms aids in developing targeted therapeutic interventions.
Better insights into bone quality factors contribute to reducing fracture risk in osteoporosis patients.