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[Hodgkin's disease associated with LDH-M subunit deficiency]
1First Department of Internal Medicine, Toho University School of Medicine, Tokyo.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|November 1, 1991
Summary
This study reports the first case in Japan of Hodgkin's disease complicated by lactate dehydrogenase M (LDH-M) subunit deficiency. The patient achieved complete remission after C-MOPP therapy.
Area of Science:
- Biochemistry
- Oncology
- Genetics
Background:
- Lactate dehydrogenase M (LDH-M) subunit deficiency is a rare genetic disorder.
- Hodgkin's disease is a cancer of the lymphatic system.
Observation:
- A 60-year-old man presented with cervical swelling and was diagnosed with stage IA Hodgkin's disease.
- Laboratory tests revealed homogeneous type 1 lactate dehydrogenase (LDH-H4) in serum and erythrocytes, indicating LDH-M subunit deficiency.
- The patient did not exhibit typical symptoms like muscle rigidity or myoglobinuria.
Findings:
- The patient received C-MOPP chemotherapy and irradiation, achieving complete remission.
- This case represents the first reported instance of LDH-M subunit deficiency co-occurring with Hodgkin's disease in Japan.
- Only five families with LDH-M subunit deficiency have been previously reported in Japan.
Implications:
- This case expands the known clinical spectrum of LDH-M subunit deficiency.
- It highlights the importance of considering rare genetic conditions in cancer patients.
- Further research may elucidate potential links between LDH-M deficiency and cancer susceptibility or progression.