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Updated: Jul 14, 2026
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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
Autosomal dominant polycystic kidney disease - a systemic disorder
1Department of Medicine, University of Nairobi, P.O. Box 19676, Nairobi.
African Journal of Health Sciences
|June 22, 2007
Summary
Autosomal dominant polycystic kidney disease (ADPKD) affects multiple organs beyond the kidneys, impacting overall health. Understanding these systemic effects is crucial for managing ADPKD
Area of Science:
- Genetics and Medicine
- Nephrology
- Systemic Diseases
Background:
- Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder.
- While primarily known for kidney cysts, ADPKD affects multiple organs.
- Systemic involvement significantly contributes to ADPKD morbidity and mortality.
Purpose of the Study:
- To review the pattern and prevalence of extra-renal organ involvement in ADPKD.
- To highlight ADPKD as a systemic disease rather than solely a renal disorder.
Main Methods:
- Literature review of studies on ADPKD organ involvement.
- Analysis of prevalence and patterns of extra-renal manifestations.
Main Results:
- ADPKD frequently involves organs such as the liver, pancreas, spleen, and central nervous system.
- The extent and type of organ involvement vary among patients.
- Extra-renal manifestations are significant contributors to patient outcomes.
Conclusions:
- ADPKD is a systemic disease with widespread organ involvement.
- Recognizing and managing extra-renal manifestations is essential for comprehensive ADPKD care.
- Further research into the mechanisms and management of systemic ADPKD is warranted.
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