Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age, hypertension and arterial function.

Carmel M McEniery1, Ian B Wilkinson, Albert P Avolio

  • 1Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. cmm41@cam.ac.uk

Clinical and Experimental Pharmacology & Physiology
|June 22, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Central Systolic Blood Pressure and Left Ventricular Mass: Findings From the International 24-Hour Aortic Blood Pressure Consortium.

Journal of the American Heart Association·2026
Same author

GOLD 2026 COPD ABE assessment tool to identify individuals at high risk in a UK multicentre COPD cohort (ERICA).

BMJ open respiratory research·2026
Same author

Novel hypertension phenotypes based on cross-classification of 24-h brachial and aortic SBP.

Journal of hypertension·2026
Same author

Higher skeletal muscle mass is associated with higher blood pressure and left ventricular mass.

Journal of hypertension·2026
Same author

Left atrial stiffness, exercise intolerance and injury biomarkers predict adverse outcomes in patients with heart failure with preserved ejection fraction.

NPJ cardiovascular health·2026
Same author

Accelerated Vascular Ageing: An Early Prognostic Signal for Risk Stratification and Prevention.

European journal of preventive cardiology·2026
Same journal

Relationship Between Long-Term Exposure to Airborne Particulate Matter and the Intrinsic Capacity of Middle-Aged and Older Adults in China: A Retrospective Cohort Study Based on CHARLS.

Clinical and experimental pharmacology & physiology·2026
Same journal

Dapagliflozin Improves Mitochondrial Function to Reduce the Risk of Atrial Fibrillation in a High-Glucose Environment by Activating the AMPK/PGC-1α/SIRT3 Signalling Pathway.

Clinical and experimental pharmacology & physiology·2026
Same journal

Hypertension-Mediated Organ Damage: Pathophysiological Mechanisms, Clinical Consequences, and Implications for Early Risk Stratification.

Clinical and experimental pharmacology & physiology·2026
Same journal

Saikosaponin D Alleviates Atherosclerosis by Regulating Autophagy and Senescence of VSMCs via Inhibiting EPHB2.

Clinical and experimental pharmacology & physiology·2026
Same journal

Noninvasively Evaluating the Cerebral Blood Flow Changes After Surgery in Adult Moyamoya Patients Using 3D Pulsed Arterial Spin Labelling MRI.

Clinical and experimental pharmacology & physiology·2026
Same journal

Targeting S100A8/A9 Ameliorates Heart Failure with Preserved Ejection Fraction by Modulating TLR4/NF-κB-Mediated Inflammation.

Clinical and experimental pharmacology & physiology·2026
See all related articles

Aging increases aortic stiffness, impacting cardiovascular health. Hypertension complicates arterial stiffness measurements, necessitating new therapies targeting large arteries directly for better cardiovascular outcomes.

Area of Science:

  • Cardiovascular physiology
  • Gerontology
  • Vascular biology

Background:

  • Aging significantly affects the cardiovascular system, particularly large arteries, leading to increased aortic stiffness.
  • Arterial stiffness is closely linked to hypertension, but the relationship is complex due to confounding factors like mean arterial pressure.
  • Existing studies show stiffer peripheral and central arteries in hypertensive individuals, with isolated systolic hypertension uniquely affecting aortic stiffness.

Purpose of the Study:

  • To review the impact of aging on arterial stiffness.
  • To explore the complex relationship between arterial stiffness and hypertension.
  • To discuss current and potential future therapeutic strategies for reducing arterial stiffness.

Main Methods:

  • Review of cross-sectional studies assessing arterial stiffness using various techniques.

Related Experiment Videos

  • Analysis of the influence of mean arterial pressure as a confounder in arterial stiffness measurements.
  • Examination of evidence regarding arterial stiffness in different types of hypertension.

    • Main Results:

    • Aging is associated with increased aortic stiffness, while peripheral artery changes are less pronounced.
    • Hypertension, particularly mixed and isolated systolic types, is linked to increased arterial stiffness.
    • Current antihypertensive drugs primarily reduce stiffness indirectly by lowering blood pressure.

    Conclusions:

    • Directly targeting large artery stiffness is crucial for effective cardiovascular treatment.
    • Functional therapies like nitric oxide donors and phosphodiesterase inhibitors show promise.
    • Inhibiting advanced glycation end-product cross-links offers a potential therapeutic avenue for reducing arterial stiffness.