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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Cdc42: a signal coordinator in hematopoietic stem cell maintenance

Linda Yang1, Yi Zheng

  • 1Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA.

Cell Cycle (Georgetown, Tex.)
|June 22, 2007
PubMed

Maintenance of a relatively quiescent cell cycle state is a distinct characteristic of adult hematopoietic stem cells (HSCs) residing in the bone marrow (BM) microenvironment. This property is considered critical for HSCs to fulfill long term self-renewal and multi-lineage differentiation potential throughout mammalian life span. To date, the mechanisms regulating the cell cycle state and the retention of HSCs in the BM microenvironment remain unclear. Cdc42, a small GTPase of the Rho family known to control various cellular functions including adhesion, migration, transcription, and growth, is shown recently in a conditional gene-targeted mouse model to coordinate HSC quiescence maintenance and BM niche residency. The study also highlights a cell-type specific role of Cdc42 in cell cycle regulation.

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