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Related Experiment Videos

Aptamers: molecular tools for analytical applications.

Teresa Mairal1, Veli Cengiz Ozalp, Pablo Lozano Sánchez

  • 1Nanobiotechnology and Bioanalysis Group, Department of Chemical Engineering, Universitat Rovira i Virgili, 43007, Tarragona, Spain.

Analytical and Bioanalytical Chemistry
|June 22, 2007
PubMed
Summary
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Aptamers are artificial nucleic acid ligands selected using systematic evolution of ligands by exponential enrichment (SELEX). These molecules show promise for various analytical applications, including drug discovery and biosensing.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Analytical Chemistry

Background:

  • Aptamers are artificial nucleic acid ligands that bind to specific targets.
  • Naturally occurring aptamers function as genetic regulatory elements called riboswitches.
  • Artificial aptamers are generated using in vitro selection methods like SELEX.

Purpose of the Study:

  • To review the properties and selection methods of aptamers.
  • To discuss the applications of aptamers in analytical devices and techniques.
  • To highlight the advantages of aptamers over traditional affinity molecules.

Main Methods:

  • Systematic evolution of ligands by exponential enrichment (SELEX) for aptamer generation.
  • Incorporation of aptamers into molecular beacon structures.

Related Experiment Videos

  • Review of aptamer properties, selection, and stabilization methods.

    • Main Results:

    • Aptamers possess unique characteristics making them suitable for analytical applications.
    • Recent advancements facilitate efficient aptamer selection and stabilization.
    • Aptamers offer advantages over existing affinity biocomponents for various assays.

    Conclusions:

    • Aptamers are powerful tools for functional and quantitative proteomics and high-throughput drug discovery.
    • Aptamers are increasingly used in chromatography, ELISA-type assays, biosensors, and affinity PCR.
    • Future research will likely expand aptamer applications in diverse analytical fields.