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Differences among implanted pulse generator waveforms cause variations in the neural response to deep brain

Christopher R Butson1, Cameron C McIntyre

  • 1Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Avenue, ND20, Cleveland, OH 44195, USA.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|June 22, 2007
PubMed
Summary

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Deep brain stimulation (DBS) implantable pulse generators produce different waveforms than expected, impacting neural response predictions. Accounting for actual waveforms is crucial for accurate DBS research and clinical analysis.

Area of Science:

  • Neuroscience
  • Biomedical Engineering

Background:

  • Deep brain stimulation (DBS) utilizes implantable pulse generators (IPGs) like Medtronic's Soletra and Kinetra.
  • Accurate stimulation waveforms are critical for effective DBS therapy.

Purpose of the Study:

  • To compare the stimulation waveforms generated by two different Medtronic IPG models (Soletra and Kinetra).
  • To assess the impact of waveform discrepancies on predicted neural responses.

Main Methods:

  • Recorded stimulation waveforms across various parameter settings for each IPG model.
  • Compared recorded waveforms to idealized programming parameters.
  • Utilized a computational model to predict neural activation thresholds.

Main Results:

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  • IPG-generated waveforms deviated from idealized parameters, with model-specific differences.
  • Discrepancies increased at higher frequencies and longer pulse widths.
  • Waveform variations caused up to 0.4 V differences in predicted neural activation thresholds.

    • Conclusions:

    • Actual DBS stimulation waveforms significantly influence neural responses.
    • Theoretical and experimental DBS studies must incorporate actual IPG waveforms.
    • Unaccounted waveform differences represent a source of error in DBS research and clinical measurements.