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Updated: Jul 14, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
Successful treatment of ventricular assist device associated ventricular thrombus with systemic tenecteplase
H Hayes1, L Dembo, R Larbalestier
1Advanced Heart Failure & Cardiac Transplant Service, Royal Perth Hospital, Perth, Western Australia, Australia. helen.hayes@health.wa.gov.au
Abstract:
We report a case of intracardiac thrombus in a patient supported by the Jarvik 2000 Flowmaker successfully treated with a single dose of peripherally administered TNK-tissue plasminogen activator (Tenecteplase, Metalyse, Boehringer Ingelheim). This strategy may be considered in the case of life-threatening VAD associated thrombosis to avoid the need for intracardiac drug delivery or VAD replacement. We also discuss the apparent increased thrombotic risk in patients receiving a VAD for chemotherapy induced cardiomyopathy and the implications this may have for the choice of VAD.
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