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Updated: Jul 14, 2026

Purification of Endogenous Drosophila Transient Receptor Potential Channels
Published on: December 28, 2021
TRP channel structural biology: new roles for an old fold
Benjamin R Myers1, David Julius
1Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA. benjamin.myers@ucsf.edu
Abstract:
The capsaicin receptor, TRPV1, contributes to thermal and chemical sensitivity of primary afferent neurons of the pain pathway, but many aspects of its regulation remain elusive. In this issue of Neuron, Lishko et al. describe a high-resolution structure of a TRPV1 domain, providing insight into the molecular basis of channel modulation while revealing new functions for a widely expressed protein interaction fold.
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