Related Experiment Video
Updated: Jul 14, 2026

Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow
Published on: July 29, 2018
Myeloid lineage commitment from the hematopoietic stem cell
Hiromi Iwasaki1, Koichi Akashi
1Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Abstract:
Prospective isolation of hematopoietic stem and progenitor cells has identified the lineal relationships among all blood-cell types and has allowed their developmental mechanisms to be assayed at the single-cell level. These isolated cell populations are used to elucidate the molecular mechanism of lineage fate decision and of its plasticity directly by stage-specific enforcement or repression of lineage-instructive signaling in purified cells. With an emphasis on the myeloid lineage, this review summarizes current concepts and controversies regarding adult murine hematopoietic development and discusses the potential mechanisms, operated by single or by multiple transcription factors, of myeloid lineage fate decision.
Related Concept Videos
Lineage Commitment
Production of Formed Elements
Most HSCs commit to...
Multipotency of Hematopoietic Stem Cells
Hematopoiesis
Differentiation of Common Myeloid Progenitor Cells
Regulation of Hematopoietic Stem Cells

