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Updated: Jul 14, 2026
09:31
Calcium Carbonate Formation in the Presence of Biopolymeric Additives
Published on: May 14, 2019
Improving the compaction properties of roller compacted calcium carbonate
C Bacher1, P M Olsen, P Bertelsen
1Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, DK-2100 Universitetsparken 2, Copenhagen, Denmark.
International Journal of Pharmaceutics
|June 22, 2007
Summary
Roller compaction of calcium carbonate with sorbitol improved tablet compression. Material properties like calcium carbonate morphology and sorbitol particle size were key, ensuring robust flow and compactibility for production scale tablet presses.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Roller compaction is a key granulation method in pharmaceutical manufacturing.
- Understanding the influence of material properties on compaction is crucial for process optimization.
Purpose of the Study:
- To investigate the impact of roller compaction parameters, calcium carbonate morphology, and sorbitol particle size on granule properties.
- To assess the robustness and flowability of granules for production scale tablet pressing.
- To evaluate the effect of sorbitol addition on the compressibility and compactibility of calcium carbonate.
Main Methods:
- Investigated effects of roller compaction parameters, calcium carbonate morphology, and sorbitol particle size.
- Assessed flow, compaction, and compression properties using a compaction simulator and a rotary tablet press.
- Analyzed compressibility using the Walker coefficient W(ID) and compactibility using C(P).
Main Results:
- Calcium carbonate morphology and sorbitol particle size significantly influenced compaction properties more than roller settings.
- Roller compaction demonstrated robust and stable flowability and compactibility.
- Granule flowability was sufficiently improved for production scale rotary tablet pressing.
- Addition of sorbitol enhanced calcium carbonate compressibility and compactibility.
- Correlation between consolidation characteristics was observed.
- Compaction simulator data correlated with tablet press results for specific calcium carbonate forms (cubic and ground).
Conclusions:
- Material properties, specifically calcium carbonate morphology and sorbitol particle size, are critical determinants in roller compaction.
- The roller compaction process is reliable for achieving adequate flowability and compactibility for pharmaceutical production.
- Sorbitol addition is an effective strategy to improve the compression and compaction behavior of calcium carbonate.
- Compaction simulation can reliably predict performance on production scale tablet presses for certain materials.
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