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Updated: Jul 14, 2026
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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
[Stroke in newborn infants]
Suada Heljić1, Amela Mornjaković, Zulejka Merhemić
1Pedijatrijska klinika, KCU Sarajevo. sheljic@hotmail.com
Medicinski Arhiv
|June 23, 2007
Summary
Neonatal stroke, particularly middle cerebral artery infarction, can occur in term infants presenting with seizures. Early suspicion via ultrasonography and confirmation with advanced imaging like MRI are crucial for diagnosis.
Area of Science:
- Neurology
- Pediatrics
- Radiology
Background:
- Stroke in newborns is a significant concern, affecting approximately 1 in 4000 live births.
- Cerebrovascular events in neonates have diverse etiologies and pathogenesis that require further elucidation.
- Term infants are more frequently affected, often presenting with seizures within the first few days of life.
Observation:
- A case of a term newborn diagnosed with middle cerebral artery infarction is presented.
- The neonate, initially admitted for meconial aspiration syndrome, developed generalized seizures on the third day of life.
- Routine brain ultrasonography indicated a high suspicion of middle cerebral artery infarction.
Findings:
- Diagnosis was confirmed using computed tomography (CT), magnetic resonance imaging (MRI), and MR angiography.
- The infant exhibited no coagulation disturbances or other identifiable risk factors for stroke.
- Seizures in the first 1-4 days of life in term infants warrant consideration of cerebrovascular insult.
Implications:
- Brain ultrasonography can serve as an initial screening tool for suspected middle cerebral artery infarction.
- Definitive diagnosis necessitates advanced neuroimaging techniques including CT, MRI, and angiography.
- Prompt and accurate diagnosis is essential for appropriate management of neonatal stroke.
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