Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Longitudinal Research

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Alzheimer Disease l: Introduction

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

Life Tables

Life Tables

A life table is a statistical tool that summarizes the mortality and survival patterns of a population, providing detailed insights into the likelihood of survival or death across different age intervals within a cohort. By organizing data on survival probabilities and mortality rates, life tables offer a clear snapshot of population dynamics over time. They are extensively used in demography, public health, actuarial science, and ecology to analyze life expectancy, design health interventions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hidden familial cardiomyopathies in children: Role of genetic testing.

International journal of cardiology·2021

Same author

A randomized trial to study the effect of automatic cluster remover settings on milking performance, teat condition, and udder health.

Journal of dairy science·2020

Same author

Cilostazol reduces dry eye symptoms and improve walking distance in patients with peripheral artery disease.

La Clinica terapeutica·2019

Same author

Major right pulmonary artery to left atrium fistula successfully treated with Amplatzer muscular ventricular septal defect occluder.

European heart journal. Cardiovascular Imaging·2018

Same author

Single-Incision Laparoscopic Cholecystectomy: our experience and review of literature.

Il Giornale di chirurgia·2016

Same author

Elevated chromogranin A serum levels in ovarian carcinoma patients.

Indian journal of cancer·2014

Search research articles

Related Experiment Video

Updated: Jul 14, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Cognitive and functional status in the extreme longevity.

M Motta¹, L Ferlito, S U Magnolfi

¹Department of Senescence Sciences, University of Catania, Cannizzaro Hospital, Via Messina 829, I-95126 Catania, Italy. lmotta@unict.it

Archives of Gerontology and Geriatrics

|June 23, 2007

Summary

Cognitive decline is more frequent in centenarians than the general elderly population. Good cognitive function and health are essential, but not sufficient, for maintaining autonomy in very old age.

More Related Videos

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

Published on: February 13, 2020

Related Experiment Videos

Last Updated: Jul 14, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

Published on: February 13, 2020

Area of Science:

Gerontology
Neurology
Epidemiology

Background:

Cognitive decline, affecting intellect, attention, processing, and memory, typically emerges after age 70.
While numerous studies document age-related cognitive deterioration, few explore its impact on the clinical status and autonomy of long-living individuals.
Understanding cognitive function in centenarians is crucial for assessing their overall health and independence.

Purpose of the Study:

To investigate cerebral deterioration in centenarians.
To correlate cognitive function with clinical conditions and autonomy in centenarians.
To determine the prevalence and impact of cognitive disorders in extreme longevity.

Main Methods:

Analysis of 346 centenarians (age 100-109) from the Italian multi-center study on centenarians (IMUSCE).
Assessment of cognitive function using the Mini-Mental State Examination (MMSE).
Evaluation of functional autonomy via Instrumental Activities of Daily Living (IADL) and clinical conditions (Groups A, B, C).

Main Results:

54.1% of examined centenarians had a normal MMSE score.
Cognitive disorders were significantly more frequent in centenarians (13.1%) compared to the general elderly (5.1%).
Severe cognitive impairment precluded total autonomy; only 1.7% of centenarians were fully independent, possessing good cognition and clinical health.

Conclusions:

Cognitive disorders are highly prevalent in centenarians.
Normal cognitive scores and good clinical conditions are necessary but insufficient for complete autonomy in Instrumental Activities of Daily Living.
Maintaining autonomy in extreme longevity requires a complex interplay of cognitive, clinical, and functional factors.