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Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

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Related Experiment Video

Updated: Jul 14, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Marginal-zone lymphoma.

Andrés J M Ferreri1, Emanuele Zucca

  • 1Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy. andres.ferreri@hsr.it

Critical Reviews in Oncology/Hematology
|June 23, 2007
PubMed
Summary

Marginal-zone lymphoma (MZL) comprises three subtypes with distinct clinical and biological features. Research indicates these lymphomas may originate from various marginal-zone B-cell subsets and are linked to chronic infections.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Marginal-zone lymphoma (MZL) is a group of B-cell lymphomas including MALT lymphoma, nodal MZL, and primary splenic MZL.
  • These subtypes exhibit significant clinical and biological heterogeneity based on their organ of origin.
  • Marginal-zone B-cells are functionally diverse, with variations in Ig variable gene somatic hypermutation patterns.

Purpose of the Study:

  • To explore the origins and pathogenesis of MZL subtypes.
  • To review current and experimental therapeutic strategies for MZL.
  • To highlight MZL as a key area for future molecular and clinical research.

Main Methods:

  • Analysis of Ig heavy chain variable gene sequences and somatic mutation patterns.
  • Review of established and experimental therapeutic approaches.

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Last Updated: Jul 14, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
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Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro

Published on: November 26, 2018

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08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

  • Correlation of pathogenesis with chronic infectious agents.

    • Main Results:

    • Sequence and mutation analysis suggest MZL can arise from different marginal-zone B-cell subsets.
    • Pathogenesis is frequently associated with chronic infections such as H. pylori, HCV, C. jejuni, C. psittaci, and B. burgdorferi.
    • Standard treatments include surgery, radiotherapy, and chemotherapy, with experimental options like antimicrobial therapy, anti-CD20 therapy, and immunotherapy.

    Conclusions:

    • MZL subtypes display distinct characteristics influenced by their site of origin.
    • Chronic infections play a role in the pathogenesis of MZL.
    • While therapeutic options exist, further prospective trials and universally accepted guidelines are needed for these lymphomas.