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[Retinopathy of prematurity in the XXI century in a developing country: an emergency that should be resolved]
1Area de Neonatología y Seguimiento de Alto Riesgo, Buenos Aires, Argentina. arquerol@fibertel.com.ar
Insights
Retinopathy of prematurity (ROP) is a growing epidemic in Argentina, causing childhood blindness. This study found that severe ROP occurred in larger, more mature infants, suggesting healthcare disparities in prevention strategies.
Area of Science:
- Ophthalmology
- Neonatology
- Public Health
Context:
- Retinopathy of prematurity (ROP) is a leading cause of childhood blindness in Argentina, reaching epidemic levels.
- Analysis of ROP cases at a major pediatric hospital provides insights into the characteristics of affected infants.
- Understanding ROP's epidemiology is crucial for developing effective prevention and treatment strategies.
Purpose:
- To analyze the characteristics of infants referred for very severe Retinopathy of Prematurity (ROP) in Buenos Aires.
- To investigate factors associated with ROP, including gestational age, birth weight, and geographical origin of referral centers.
- To identify potential disparities in healthcare that contribute to the ROP epidemic.
Summary:
- A retrospective study of 809 infants with ROP from 1996-2003 revealed an increasing trend in very severe cases.
- A significant proportion of infants (14%) were considered 'unusual' ROP cases (gestational age > 31 weeks or birth weight > 1500g).
- Infants from distant referral centers (Group B) had higher gestational ages and lower rates of mechanical ventilation, indicating potential healthcare access differences.
Impact:
- The study highlights an epidemic of childhood blindness due to ROP, with severe cases appearing in larger, more mature newborns.
- Findings suggest significant disparities in healthcare provision and ROP management across different regions.
- The results underscore the need for targeted prevention strategies to address the ROP epidemic and reduce childhood blindness.
Introduction:
Retinopathy of prematurity (ROP) is the first cause of childhood blindness in Argentina and is reaching epidemic proportions. To gain greater insight into the issues involved in this epidemic, we analyzed the characteristics of the infants referred for treatment of very severe ROP to the Dr. Juan P. Garrahan Pediatric Hospital, located in the city of Buenos Aires.
Methods:
We performed a retrospective study of patients referred for ROP from 01/01/96 to 12/31/03. Very severe ROP was defined as threshold disease or worse in both eyes, plus disease in zones 1 or 2, or Rush disease. Unusual patients were defined as those with very severe ROP with a gestational age (GA) of > 31 weeks or birth weight (BW) > 1500 g. Patients were divided into two groups according to the distance between the referring center and our hospital: group A consisted of those from nearby areas (
Results:
During the study period, the number of cases progressively increased while the proportion of "unusual" patients slightly decreased. The total number of infants referred was 809 and 14 % were unusual patients; 55 % had very severe ROP, 89 % were treated, and 7 % were referred too late and lost the opportunity for treatment. Group B comprised 61 % of the infants referred. Very severe ROP was present in 53 % of patients in group A and in 56 % of those in group B. The mean GA was 29.5 +/- 3.1 weeks in group A and 30.8 +/- 2.6 in group B (p < 0.001); 90.5 % of the patients in group A and 64 % of those in group B required mechanical ventilation (p < 0.001). No predictors for very severe ROP were found in multifactorial analysis.
Conclusions:
We report a childhood epidemic of blindness in which the prevalence of very severe ROP increased during the study period and the disease occurred in large, fairly mature newborns. The differences found in relation to the referring center and the lack of correlation between very severe ROP and prematurity or the use of mechanical ventilation suggests substantial disparity in healthcare, which should be taken into account when planning prevention strategies.
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