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Sequence composition effects on denatured state loop formation in iso-1-cytochrome c variants: polyalanine versus

Franco O Tzul1, Eydiejo Kurchan, Bruce E Bowler

  • 1Department of Chemistry and Center for Biomolecular Structure and Dynamics, University of Montana, Missoula, MT 59812, USA.

Journal of Molecular Biology
|June 23, 2007
PubMed
Summary

Protein loop formation, crucial for folding, is not significantly aided by glycine's flexibility compared to alanine. Steric properties, not just flexibility, influence loop stability in proteins like cytochrome c.

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