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Updated: Jul 14, 2026

Measuring Synaptic Vesicle Endocytosis in Cultured Hippocampal Neurons
Published on: September 4, 2017
Models of active transport of neurotransmitters in synaptic vesicles
Alexey V Melkikh1, Vladimir D Seleznev
1Molecular Physics Chair, Ural State Technical University, 19 Mira Street, 620002 Yekaterinburg, Russia. mav@dpt.ustu.ru
Abstract:
Models of the active transport of neurotransmitters in synaptic vesicles were constructed. The models were used to determine the resting potential at membranes of synaptic vesicles: 40mV (monoamines and acetylcholine) and -40mV (glutamate). The potential at the membrane of a synaptic vesicle was almost absent for the transport of GABA and glycine. The neurotransmitter concentration of a cell was 0.1-18mM at the concentration of neurotransmitters in a vesicle equal to 0.5M. This result is in qualitative agreement with the relevant experimental data.
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