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Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

[Local immunotherapy prevention of recurrent respiratory infections in children]

M C Venturi1, A Biolchini, M Bardare

  • 1Clinica Pediatrica I, Università degli Studi di Milano.

Minerva Pediatrica
|September 1, 1991
PubMed

Insights

Local immunotherapy significantly reduced recurrent respiratory infections in children. Treatment increased salivary immunoglobulin A (S-IgA) levels, enhancing immune response.

Area of Science:

  • Pediatric immunology
  • Respiratory medicine
  • Immunotherapy

Context:

  • Recurrent respiratory infections pose a significant health burden in children.
  • Assessing the efficacy of local immunotherapy in pediatric patients is crucial for managing frequent infections.

Purpose:

  • To evaluate the effectiveness of local immunotherapy (Biomunil spray) in reducing recurrent respiratory infections in children.
  • To assess the impact of immunotherapy on salivary and serum immunoglobulin levels.

Summary:

  • A six-month trial involved 20 children (2.5-10 years) with over 6 respiratory infections annually.
  • Treatment with Biomunil spray led to a statistically significant decrease in upper respiratory infections (p<0.001).
  • Immunotherapy also significantly increased salivary immunoglobulin A (S-IgA) levels (p<0.001) and showed a trend towards lower serum IgA and IgG.

Impact:

  • Local immunotherapy demonstrates potential as an effective strategy for managing recurrent respiratory infections in children.
  • The observed increase in S-IgA suggests an enhancement of mucosal immunity.
  • The treatment was well-tolerated and showed good compliance, indicating its practical applicability.

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