Related Experiment Videos
[Local immunotherapy prevention of recurrent respiratory infections in children]
M C Venturi1, A Biolchini, M Bardare
1Clinica Pediatrica I, Università degli Studi di Milano.
Insights
Local immunotherapy significantly reduced recurrent respiratory infections in children. Treatment increased salivary immunoglobulin A (S-IgA) levels, enhancing immune response.
Area of Science:
- Pediatric immunology
- Respiratory medicine
- Immunotherapy
Context:
- Recurrent respiratory infections pose a significant health burden in children.
- Assessing the efficacy of local immunotherapy in pediatric patients is crucial for managing frequent infections.
Purpose:
- To evaluate the effectiveness of local immunotherapy (Biomunil spray) in reducing recurrent respiratory infections in children.
- To assess the impact of immunotherapy on salivary and serum immunoglobulin levels.
Summary:
- A six-month trial involved 20 children (2.5-10 years) with over 6 respiratory infections annually.
- Treatment with Biomunil spray led to a statistically significant decrease in upper respiratory infections (p<0.001).
- Immunotherapy also significantly increased salivary immunoglobulin A (S-IgA) levels (p<0.001) and showed a trend towards lower serum IgA and IgG.
Impact:
- Local immunotherapy demonstrates potential as an effective strategy for managing recurrent respiratory infections in children.
- The observed increase in S-IgA suggests an enhancement of mucosal immunity.
- The treatment was well-tolerated and showed good compliance, indicating its practical applicability.
Abstract:
A group of 20 children aged between 2.5 and 10 years with recurrent respiratory infections (greater than 6/year) was treated with local immunotherapy (Biomunil spray) for a six-month period (October-March 1988/89). Referring to the same period on last year, a statistically significant decrease of upper respiratory infections was observed (p less than 0.001) as well as an increase of S-IgA rate (p less than 0.001) and less of serum IgA and IgG. The compliance and the tolerance of the drug was good.