Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial function: a surrogate endpoint in cardiovascular studies?

Matthias Frick1, Franz Weidinger

  • 1Division of Cardiology, Innsbruck Medical University, Austria.

Current Pharmaceutical Design
|June 23, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Killip class at presentation and immediate versus staged multivessel PCI in patients with STEMI.

Scientific reports·2026
Same author

Environmental risk factors and cardiovascular health.

European heart journal·2026
Same author

Management of dyslipidaemia in patients with comorbidities - facing the challenge: Heart failure.

European heart journal. Cardiovascular pharmacotherapy·2026
Same author

Impact of renal dysfunction on immediate versus staged revascularization of non-culprit lesions in patients with ST segment elevation myocardial infarction: a pre-specified subgroup analysis of the randomized MULTISTARS AMI trial.

Clinical research in cardiology : official journal of the German Cardiac Society·2026
Same author

Post-certification competencies and cardiovascular care delivery.

European heart journal·2026
Same author

Clinical practice guideline implementation: challenges and solutions for improved cardiovascular care: A Report from the European Society of Cardiology Cardiovascular RoundTable.

European heart journal. Quality of care & clinical outcomes·2026

Endothelial dysfunction, an early sign of atherosclerosis, can be detected using non-invasive tests. These methods offer prognostic value for cardiovascular health and are crucial for early disease detection.

Area of Science:

  • Cardiovascular Research
  • Vascular Biology

Background:

  • Endothelial dysfunction is an early indicator of atherosclerosis, preceding structural changes and clinical symptoms.
  • Detecting endothelial dysfunction is crucial for early diagnosis and intervention in cardiovascular disease.

Purpose of the Study:

  • To review the current status of endothelial dysfunction as an early marker of atherosclerosis.
  • To critically evaluate the prognostic value and clinical utility of endothelial function tests.

Main Methods:

  • Review of studies on endothelial dysfunction detection in humans.
  • Focus on non-invasive techniques like flow-mediated vasodilation and strain-gauge venous plethysmography.
  • Analysis of prognostic impact, safety, and reproducibility of these tests.

Related Experiment Videos

Main Results:

  • Intracoronary acetylcholine infusion, while informative, is too invasive for widespread clinical use.
  • Non-invasive methods demonstrate prognostic value in diverse patient populations.
  • Endothelial function serves as a valuable surrogate endpoint in cardiovascular studies.

Conclusions:

  • Non-invasive endothelial function tests are vital for early atherosclerosis detection and risk assessment.
  • These tests hold significant potential for clinical application and cardiovascular research.
  • Further validation confirms the role of endothelial dysfunction in predicting cardiovascular events.