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Related Concept Videos

Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...

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Related Experiment Video

Updated: Jul 14, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

Natural peroxy anticancer agents.

Valery M Dembitsky1, Tatyana A Gloriozova, Vladimir V Poroikov

  • 1Department of Medicinal, Chemistry and Natural Products, School of Pharmacy, Hebrew University, Jerusalem, Israel. dvalery@cc.huji.ac.il

Mini Reviews in Medicinal Chemistry
|June 23, 2007
PubMed
Summary

Natural products from land and sea offer promising anticancer agents, with over 120 showing in vitro activity. Limited supply necessitates total synthesis for further drug development.

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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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Published on: March 20, 2018

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Area of Science:

  • Natural product chemistry
  • Pharmacology
  • Drug discovery

Background:

  • Terrestrial and marine organisms are rich sources of novel anticancer compounds.
  • Over 120 cytotoxic agents have demonstrated in vitro activity against tumor cell lines.
  • Many natural products show potential but face development hurdles due to limited supply.

Purpose of the Study:

  • To review novel natural anticancer agents from terrestrial and marine sources.
  • To highlight the importance of total synthesis for overcoming supply limitations.
  • To explore potential new applications predicted by computational analysis.

Main Methods:

  • Literature review of natural product research.
  • Analysis of in vitro bioassay data for cytotoxic activity.
  • Discussion of total synthesis strategies for natural products.
  • Mention of computational prediction of biological activities using PASS.

Main Results:

  • Identification of over 120 cytotoxic compounds from natural sources.
  • Discovery of numerous potent cytotoxic agents from terrestrial and marine organisms.
  • Emphasis on terrestrial and marine peroxides as key sources for drug leads.

Conclusions:

  • Natural products, particularly peroxides, are vital for discovering new anticancer drugs.
  • Total synthesis is crucial for advancing natural product-derived drug candidates.
  • Further research is needed to overcome supply challenges and advance natural products into clinical use.