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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

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Related Experiment Video

Updated: Jul 14, 2026

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
09:54

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection

Published on: February 16, 2020

Tuberculosis: diagnostics.

Sang-Nae Cho1, Patrick J Brennan

  • 1Department of Microbiology, Yonsei University College of Medicine, 134 Shinchon-dong, Seoul 120-752, South Korea. raycho@yumc.yonsei.ac.kr

Tuberculosis (Edinburgh, Scotland)
|June 23, 2007
PubMed
Summary

Molecular diagnostic tests, including nucleic acid detection and mutation analysis, are advancing tuberculosis (TB) diagnosis. These new methods address challenges in drug-resistant, pediatric, and HIV-associated TB.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Infectious Diseases

Background:

  • Microscopy and culture remain primary methods for tuberculosis (TB) diagnosis.
  • Recent advancements include molecular diagnostic tests developed over the past two decades.
  • These molecular methods target Mycobacterium tuberculosis-specific nucleic acids and drug resistance mutations.

Purpose of the Study:

  • To review the evolution and application of molecular diagnostic tools for TB.
  • To discuss new diagnostic tools for drug-resistant Mycobacterium tuberculosis.
  • To address challenges in applying new diagnostics for multidrug-resistant (MDR)-TB, pediatric TB, and HIV-TB.

Main Methods:

  • Nucleic acid detection using amplification techniques like polymerase chain reaction (PCR) for Mycobacterium tuberculosis DNA and RNA.

Related Experiment Videos

Last Updated: Jul 14, 2026

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
09:54

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection

Published on: February 16, 2020

  • Detection of gene mutations associated with anti-tuberculosis drug resistance via sequencing or nucleic acid hybridization.

    • Main Results:

    • Development of new diagnostic tools for drug-resistant M. tuberculosis.
    • Identification of issues in applying novel diagnostic tools for complex TB cases.
    • Focus on molecular detection of M. tuberculosis and its resistance patterns.

    Conclusions:

    • Molecular diagnostics represent a significant evolution in TB laboratory diagnosis.
    • New tools are crucial for addressing challenges in drug resistance, pediatric, and HIV-coinfected TB cases.
    • Continued development and application of molecular methods are essential for improved TB management.