Related Experiment Video
Updated: Jul 14, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Automated red cell exchange procedures in patients with sickle cell disease
Ilknur Kozanoglu1, Can Boga, Hakan Ozdogu
1Department of Physiology, Baskent University, Faculty of Medicine, 06490-Ankara, Turkey.
Abstract:
In automated red cell exchange, about 60% of the patient's red blood cells are exchanged via apheresis for those of the donor. We report the outcome of 83 patients with sickle cell anemia (48 women and 35 men; age range, 17-49 years) who underwent a total of 196 apheresis procedures between December 2003 and October 2006 at our institution. We found that automated red cell exchange involving a reduced citrate infusion rate may provide benefit in the prevention or treatment of vaso-occlusive complications in patients with sickle cell disease and may be associated with protean effects on biochemical dynamics.
Related Concept Videos
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Continuous Renal Replacement Therapy
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
