Related Experiment Video
Updated: Jul 14, 2026
Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
Selective inhibition of CBP/p300 HAT
Vasiliki Sarli1, Athanassios Giannis
1Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany. sarli@uni-leipzig.de
Abstract:
In this issue of Chemistry & Biology, Mantelingu and colleagues present the development of the garcinol derivative LTK-14, which is a specific and nontoxic inhibitor of histone acetyltransferase p300-HAT [1]. Interestingly, it blocks histone acetylation of HIV-infected cells resulting in inhibition of the multiplication of HIV in these cells.
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