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Updated: Jul 14, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
[Effect of saikosaponin alpha on experimental epilepsy in rats]
Chang-zheng Li1, Wei Xie, Yong Bao
1Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. lcztcm@126.com
Objective:
To investigate the effect of saikosaponin alpha (SSalpha) on experimental epilepsy in rats.
Methods:
Acute epileptic seizure was induced by pentylenetetrazole (PTZ) in rats, and the seizure incubation period and the number of rats with tetanic convulsion were recorded to study the antiepileptic effect of SSalpha.
Results:
After treatment with SSalpha, the incubation period of PTZ-induced seizure was significantly prolonged (P<0.01), and the rate of tetanic convulsion was significantly reduced (P<0.05).
Conclusion:
SSalpha can inhibit epileptic seizure induced by PTZ.
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